As part of our commitment to the understanding of mood and attention disorders, several of us at CPA are involved in research studies. These research efforts are wholly separate from our clinical work. Our patients are free to participate or not participate in any of these projects. Should you wish to learn more about any of these studies, feel free to enquire with the contact person associated with it.

What follows below is a list of current research projects that we are conducting.

Circadian Phase in Bipolar Depression.                                  Principal Investigator:  John Gottlieb, M.D.
                                                                                            Contact Person: Young Jun Lee, 312 503 1948

Do you have bipolar disorder? Have you ever felt out of synch when depressed, like your timing was off? This non-clinical, Northwestern University-based study is examining biological rhythms in bipolar depression. It seeks to determine whether circadian processes vary between depressed and euthymic (normal mood state) phases of bipolar disorder. The non-clinical nature of the study means that it will not involve, nor impact your current, existing care in any way.

Who is eligible? Adults between the ages of 18 and 55 years old with a diagnosis of bipolar disorder who are currently in a depressed state.

What’s involved? After verifying your eligibility, the study has two major components. First, wearing a special, motion-detecting wristwatch for one week. Second, obtaining a set of saliva samples over a six hour period on one night. These two procedures would be conducted once, when the person is depressed, and again, after they have remitted and are in a normal mood state.
Subjects who complete the entire study are eligible for up to $400.00 in reimbursement for their time and participation.

Pain Associated with Fibromyalgia.                                              Principal Investigator: Brett Plyler, M.D.
                                                                                                   Contact Person: Dan Dwyer 773.282.9845

From widespread burning to localized stabbing, each sufferer experiences the pain associated with fibromyalgia differently. But one thing stays the same - the way that pain impacts on their day-to-day lives.
Although there are treatments available in some countries to manage this debilitating symptom, they don't work for everyone. So it's vital we continue to search for new pain relief options. That's why we're looking for volunteers to join a medical research study evaluating an investigational drug for fibromyalgia-associated pain.

Who is eligible:
Adults 18 or older who suffer from fibromyalgia.

What is involved:
Study participation will last about 21 weeks, involving 13 out-patient visits spaced apart approximately once a week to every other week. During the 13-week treatment stage, you'll take one of the following:
The investigational drug (50%)
An approved neuropathic pain treatment (25%)
A placebo (a substance containing no medication) (25%)
Throughout the study, your health will be monitored by study staff and your pain throughout the study will be recorded.

Add-on medication to treat Major Depressive Disorder               Principal Investigator: Brett Plyler, M.D.
                                                                                                      Contact Person: Dan Dwyer 773.282.9845

If feelings such as depressed mood or lack of energy are keeping you from the things that matter to you, you may be eligible for this clinical research study. It's evaluating an investigational drug designed to work with antidepressants, to see if it can help address unresolved symptoms of depression.
Whether or not you are currently taking an antidepressant, you may be eligible to participate.

Who is eligible:

  • Are 18 to 70 years of age
  • Your depression is getting in the way of your daily life.
  • Does not have other psychiatric diagnoses.

What is involved: The investigational drug is a tablet that dissolves under the tongue, and is designed to address unresolved symptoms of depression in a way that is different from currently approved medications.
Depending on your current antidepressant treatment experience and medical history, study participation is scheduled to take 16 to 24 weeks with a clinic visit every week.